en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.5pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Cardiovascular disease is a leading cause of death in chronic kidney disease (CKD) patients, with pulmonary hypertension (PH) and right ventricular (RV) dysfunction being especially detrimental. Secondary hyperparathyroidism (SHPT), common in CKD-mineral and bone disorder (CKD-MBD), has been linked to vascular problems, but its specific role in pulmonary vascular disease and RV function in hemodialysis (HD) patients remains unclear.<span lang="EN" style="font-size:10.0pt"></span></span><br> <span style="line-height:13.5pt"><b><i><span lang="EN"><span style="color:blue">Objectives: </span></span></i></b>This study examined the relationship between serum intact parathyroid hormone (iPTH), pulmonary artery pressure (PAP), and RV function in CKD patients (both on HD and pre-dialysis). The hypothesis was that higher iPTH correlates with increased PAP and worse RV function.</span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Methods:</span></i></b> A total of 115 CKD patients (69.6% HD, 30.4% pre-dialysis) were enrolled. Clinical data included iPTH, calcium, phosphorus, and albumin. Echocardiography measured pulmonary artery systolic pressure (PASP), tricuspid annular plane systolic excursion (TAPSE), and fractional area change (FAC). Statistical analyses adjusted for confounders.<span lang="EN" style="font-size:10.0pt"></span></span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Results:</span></i></b> PH prevalence was 60%. Severe PH patients had significantly higher mean iPTH (P=0.001). In the HD group, elevated iPTH strongly linked to severe PH (p<0.001); each unit iPTH increase raised PH risk by 1.01-fold (P=0.004). However, no direct iPTH&ndash;RV function association was found.<span lang="EN" style="font-size:10.0pt"></span></span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Elevated iPTH and longer HD duration are significant PH risk factors in CKD, particularly in HD patients. These findings underscore the need for CKD-MBD management and suggest that PTH-lowering therapies may reduce PH risk and improve cardiovascular outcomes. Further research is needed to identify other contributors to RV dysfunction in CKD.<span lang="EN" style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Parathyroid Hormone, Pulmonary Hypertension, Right Ventricular Function, Hemodialysis, Chronic Kidney Disease 582 588 http://caspjim.com/browse.php?a_code=A-10-3689-1&slc_lang=en&sid=1 Roghayeh Pourkia dr.pourkia@yahoo.com 100319475328460057818 100319475328460057818 No Department of Cardiology, Clinical Research Development Unit, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Mehrdad Saravi mehrdadsaravi@gmail.com 100319475328460057819 100319475328460057819 No Department of Cardiology, Clinical Research Development Unit, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Masoumeh Asgharpour masi9932002@yahoo.com 100319475328460057820 100319475328460057820 No Department of Cardiology, Clinical Research Development Unit, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Naghmeh Ziaie ziaiexn@yahoo.com 100319475328460057821 100319475328460057821 No Department of Cardiology, Clinical Research Development Unit, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Roghayeh Akbari rohanresearch88@gmail.com 100319475328460057822 100319475328460057822 No Department of Internal Medicine, Clinical Research Development Unit, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan hodashirafkan@gmail.com 100319475328460057823 100319475328460057823 No 3. Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Mohammad Nabipour mohammad.nabipoor1369@gmail.com 100319475328460057824 100319475328460057824 Yes Student Research Committee, Babol University of Medical Sciences, Babol, Iran