en Biochimestry Biochimestry Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Background: </span></b></em></span><span lang="EN-IN"><span style="line-height:150%">The prevalence of abdominal obesity is increasing rapidly worldwide and is a leading cause of morbidities and mortalities. Abdominal obesity is associated with various health complications including insulin resistance (IR), type 2 diabetes etc. The present research studied the outcome of VC intake on adiponectin (ACRP30) levels and its relationship with waist circumference (WC) and IR.</span></span></span><br> <span style="line-height:150%"><span style="color:#0033ff;"><em><b><span lang="EN-IN"><span style="line-height:150%">Methods:</span></span></b></em></span> <span lang="EN-IN"><span style="line-height:150%">The present study was carried out on a&nbsp;total of&nbsp;80 subjects. 42 obese (20 males and 22 females) and 38 non-obese (19 males and 19 females) were enrolled into two groups. Vitamin C (500 mg) was provided to all study subjects and instructed to consume it&nbsp;three times a day over a period of 90 consecutive days. Fasting blood samples were collected at the baseline and end of the study. Adiponectin levels were measured. Data were analyzed by using a&nbsp;two-tailed Student&rsquo;s t-test.</span></span></span><br> <span style="line-height:150%"><em><span style="color:#0033ff;"><b><span lang="EN-IN"><span style="line-height:150%">Results:</span></span></b></span></em><span lang="EN-IN"><span style="line-height:150%">&nbsp;Vitamin C supplementation significantly increased serum adiponectin (ACRP30) levels in obese males (P = 0.0485), obese females (P= 0.0235), non-obese males (0.0457), and non-obese females (0.0245). Adiponectin is inversely correlated with WC and IR. No significant differences were&nbsp;found in the levels of serum adiponectin between study participants gender-wise.</span></span></span><br> <span style="line-height:150%"><b><span lang="EN-IN"><span style="line-height:150%"><span style="color:#0033ff;"><em>Conclusion:</em></span> </span></span></b><span lang="EN-IN"><span style="line-height:150%">500 mg of vitamin C intake, three times a day for 90 days, is a novel potential therapeutic approach to restore the capacity of adipose tissue in secreting adiponectin and for the treatment of abdominal obesity and allied complications.<span style="font-family:&quot;Times New Roman&quot;,serif"></span></span></span></span></span></span><br> &nbsp; Vitamin C, Obesity, Adiponectin, ACRP30, Waist Circumference, HOMA-IR 21 0 http://caspjim.com/browse.php?a_code=A-10-3572-1&slc_lang=en&sid=1 Rohan Phatak phatak.rohan1983@gmail.com 100319475328460056505 100319475328460056505 Yes Department of Pharmacognosy, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India Ganesh Ghanwat ganeshghanwat07@gmail.com 100319475328460056506 0009-0007-8004-3279 No Department of Biochemistry, Govt. Medical College, Alibag-402209, Maharashtra, India Anup Hendre anupviews@gmail.com 100319475328460056507 100319475328460056507 No Department of Biochemistry, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India Ajit Sontakke ajit712@yahoo.com 100319475328460056508 100319475328460056508 No Department of Biochemistry, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India Bhagyashri Yadav bhagyashriyadav80@gmail.com 100319475328460056509 0009-0001-2526-2328 No Ph. D Scholar, Department of Biochemistry, Govt. Medical College, Alibag-402209, Maharashtra, India Amar Mohite armohitept@gmail.com 100319475328460056510 100319475328460056510 No Directorate of Research, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India